Leptin stimulates synaptogenesis in hippocampal neurons via KLF4 and SOCS3 inhibition of STAT3 signaling
GS Sahin, M Dhar, C Dillon, M Zhu, H Shiina… - Molecular and Cellular …, 2020 - Elsevier
… In contrast, shSOCS3 attenuated the effects of leptin (control = 1.15 ± 0.14 Hz; … Furthermore,
KLF4 protein is reduced in mice lacking leptin synthesis (ob/ob), suggesting that leptin is one …
KLF4 protein is reduced in mice lacking leptin synthesis (ob/ob), suggesting that leptin is one …
[PDF][PDF] Neurotrophic Actions of Leptin in Hippocampal Synaptogenesis During Development
GS Sahin - 2020 - rex.libraries.wsu.edu
… Mouse models that are deficient in leptin synthesis or … Leptin increases adult hippocampal
neurogenesis in the dentate … Attenuation of leptin action and regulation of obesity by protein …
neurogenesis in the dentate … Attenuation of leptin action and regulation of obesity by protein …
[HTML][HTML] Leptin Promotes the Proliferation and Neuronal Differentiation of Neural Stem Cells through the Cooperative Action of MAPK/ERK1/2, JAK2/STAT3 and PI3K …
R Tan, X Hu, X Wang, M Sun, Z Cai, Z Zhang… - International Journal of …, 2023 - mdpi.com
… of LepRs in both rats and mice [2]. Furthermore, LepRs were identified in the mouse embryo
as early as embryonic day (E) 10.5 [3]. In ob/ob mice, deficiency of leptin leads to reduced …
as early as embryonic day (E) 10.5 [3]. In ob/ob mice, deficiency of leptin leads to reduced …
[HTML][HTML] The role of leptin in indirectly mediating “somatic anxiety” symptoms in major depressive disorder
Y Zhu, Y Wei, J Duan, J Li, R Zhang, J Sun… - Frontiers in …, 2022 - frontiersin.org
… defects in leptin signal transduction (30). However, other studies reported reduced plasma
leptin in MDD patients with a normal BMI (16, 17); this is consistent with rats or mice models of …
leptin in MDD patients with a normal BMI (16, 17); this is consistent with rats or mice models of …
[HTML][HTML] Non-fibril form but not fibril form of human islet amyloid polypeptide 8–20 changes brain functions in mice
H Suginoma, R Owada, A Katano-Toki, A Mori… - Plos one, 2024 - journals.plos.org
… Finally, we performed tests for anxiety using the same mice because the hippocampus has
been suggested to mediate untrained anxiety reactions [23]. The tests were not performed the …
been suggested to mediate untrained anxiety reactions [23]. The tests were not performed the …